Dallas housewife Lurene Hallett's life revolves around the doings of Jacqueline Kennedy. She is devastated when President Kennedy is shot a few hours after she sees him arrive in Dallas. Despite her husband Ray's prohibition, she decides to attend the funeral in Washington, D.C. Forced to travel by bus, she befriends Jonell, the young black daughter of Paul Couter. Sensing something wrong, her good intentioned interference leads the mixed race threesome on an increasingly difficult journey to Washington with both the police and Ray looking for them.

Buddy (Affleck) has just signed an airline in Chicago as a big client, but is ironically delayed at the airport waiting for a flight to LA on that same airline. He meets fellow passenger Greg, who opts to be bumped, even though it means missing an activity with his older son. When the flight gets resumed, Buddy thinks he's doing a good deed by swapping tickets with Greg so he can get home to his son. Sadly, the flight crashes. Buddy conspires with his friend, the ticket agent that night, to take his name off the passenger list and put Greg's on. Once he's back in LA, his new client dictates that the company run a series of feel-good ads about the crash. Buddy feels very hypocritical, and completely loses it when the commercials win a Cleo. After going through re-hab, he decides he needs to check on Greg's widow. But he doesn't plan on falling in love with her.

In Manhattan, twenty-two year-old Harvard lawyer Emilia Greenleaf has a crush on her boss, Jack Woolf, and they have an affair. Jack's marriage is a sham but his son, William, is his pride and joy. Emilia soon discovers she's pregnant, and Jack divorces his wife, Carolyn, in order to marry her. His son is poisoned against the partnership by his mother, and resented by his stepmother. Emilia, who has issues with her womanizer father, delivers Isabel but the baby dies. The marriage begins to suffer and William unexpectedly steps in to help.

A 16-year-old girl visits her gay half-brother and ends up seducing his boyfriend, thus wreaking havoc on all of their lives.

An ensemble cast telling 10 stories with intertwining characters. One story is about a father and son who are dating the same woman . Another features a woman who long ago gave her baby up for adoption but is now being blackmailed by a documentary filmmaker who claims to know the now-grown child's whereabouts.